Cannabis is quickly becoming widely embraced in parts of the western world after decades of vilification and prohibition. With this acceptance comes an opening to allow scientists to research the cannabis plant and gain a deeper understanding of the chemicals generated inside. One chemical, a cannabinoid CBG, is an illustration of an untapped potential waiting to be unleashed when research in medicine.
So far, many cannabinoids such as THC and CBD have been discovered and rather well researched. These two now renowned cannabinoids have been shown to have profound medicinal effects. On account of their value, breeders have placed in the work to create strains which are particularly high in either cannabinoid so as to offer medicine or recreational buds that interest clients who can benefit off of them.
Now that research is allowing for a better comprehension of the cannabinoid CBG, breeders are starting to take note and work towards comparable scenarios using CBG heavy cannabis strains.
Although the cannabinoid CBG is classed as a little cannabinoid. It actually plays a rather significant role inside the cannabis plant. CBG exists in the kind of cannabigerolic acid (CBGA) in cannabis plants and serves as the main precursor to the 3 main branches of cannabinoids. These are: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), along with cannabichromenic acid (CBCA).
When heat is applied to CBGA, THCA, CBDA and CBCA through the mechanism of cooking or smoking, a process called decarboxylation occurs that causes their chemical structures to eliminate a carbon group. These cannabinoids are subsequently changed in the neutral forms of CBG, THC, CBD and CBC and become active.
When smoking a strain saturated in CBGA, the conversion of it into CBG will allow the consumer to acquire a dose of this cannabinoid. But since CBGA is the mother of cannabinoids, it is frequently converted into a different kind by the syntheses within plants prior to ingestion of the buds takes place. Thanks to a growing comprehension of cannabis science, and the enzymes that can cause the creation of above average levels of CBGA. Breeders have the resources to begin enhancing their breeds for this cannabinoid.
CBG appears to have the potential to combine the ranks of well-known cannabinoids when it comes to medicinal program. Research is demonstrating CBG to have a part to play in a lot of ailments.
CBG has been shown to activate the CB1 receptors of the endocannabinoid system and therefore affects the central nervous system. This effect may help to reduce some of the less desirable effects related to smoking also THC-rich cannabis, such as paranoia. CBG has also been proven to affect the CB2 receptor; however, its mechanism of action here is not yet well understood.
Researcher Ethan B Russo printed a newspaper at the British Journal of Pharmacology that takes an in-depth look at the effects of phytocannabinoids and terpenoids, their medicinal qualities and the way they could work together to generate stronger effects.
Russo says that CBG has anti-fungal properties, pain killing properties and has been proven to exhibit antidepressant properties too. CBG may also be able to tackle anxiety and muscle strain owing to its ability at preventing the uptake of a brain chemical called GABA.
Russo points out that CBG can work in combination with other elements of the cannabis plant like the terpenoids phytol, linalool, caryophyllene oxide and limonene.
Research printed in Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics analyzed the neuroprotective properties of cannabinoid CBG against Huntington’s disease in mice. Huntington’s disease is a brain disease which leads to uncontrolled movements, emotional problems and reduction of cognition with time. The researchers noticed promising results and concluded that the work opens up research paths to explore the effects of CBG either alone or in conjunction with different phytocannabinoids or remedies as soon as it concerns the treatment of esophageal diseases.
A 2009 study demonstrated that CBG can decrease intraocular pressure and can, consequently, have a use in glaucoma.
The cannabinoid CBG has also been discovered to have neurogenic properties, making it a really rare chemical that may stimulate the growth of new brain cells.
As the study of the interesting phytocannabinoid has been blossom and breeders continue to create strains with larger amounts of this molecule, CBG will, undoubtedly, be awarded its own rightful place among the pantheon of healing cannabinoids. As cannabis medication evolves over time, it will be interesting the see CBG play a role as a single cannabinoid, in addition to in combination with different elements of the cannabis plants that are showing huge potentials such as cannabinoids and terpenoids.