The Entourage Effect: Going Beyond Just THC & CBD

The Entourage Effect

CBD based drugs happen to be gaining momentum in recent years following a media frenzy around Charlotte’s Web (CWEB), a non-intoxicating cannabis breed which has been processed to some CBD-rich petroleum to an epileptic child.

The remedy prompted several countries to embrace CBD-only legislation under which THC-rich medicines stay illegal. While CBD-only cannabis medicines have proven to be life-changing for many individuals, these legislation mainly exist to help those afflicted by seizures.

The human body, naturally producing cannabinoids, has cannabinoid receptors — CB1 and CB2. CB1 receptors are mainly found in the brain and are responsible for dealing with things like pain, movement coordination, cognitive abilities (thinking, memory), appetite and emotions. CB2 receptors are more commonly found in the immune system and have an effect on things like pain and inflammation.

When CBD enters the body, it stimulates the body to create more of its own cannabinoids, thus producing the beneficial effects seen in so many patients.

Src: Charlottes Web

THC-only drugs primarily refer to synthetic renderings of THC, the 2 hottest being Marinol (dronabinol) and also Cesamet (nabilone). These are valid additives primarily prescribed to treat cancer-related nausea, but their efficacy is questionable. What’s more, it usually takes time to get a THC-only pill to provide relief where as inhaled methods take effect instantly.

Where things get really interesting is when products contain a range of cannabinoids beyond just the most well known THC and CBD. When a multitude of compounds work together in unison even stronger benefits can happen.

The notion of cannabinoids is becoming a lot more mainstream lately, for most people it used to just be indica vs. sativa, but as science progresses people are realizing there is far more to it than just that. As it turns out, whilst the cannabis plant had been used as a crude remedy for seizure disorders all through history, the Charlotte’s World strain was the plant that returned this longlost all-natural history into main stream, present day awareness.

Getting Nerdy With Cannabinoids

Cannabis is comprised of countless therapeutic chemicals called cannabinoids and terpenoids. We assume you’re well familiar with THC and CBD, however those are only two among many crucial players working together to produce certain consequences. This interactive connection between cannabis compounds has been coined the”entourage effect,” and once you know this is, you will realize why medicines containing just THC or CBD are not always adequate for many medical conditions.

The diverse chemical accessibility in entire plant drugs is notable in its own right, but research looking in to how cannabinoids and terpenoids come together adds another degree of amazement. The terpene myrcene, for example, can decrease resistance in the blood-brain barrier, allowing easier passing of other beneficial chemicals. Pinene may help counter act compromised cognition and memory due to THC.


A mixture of terpenes pinene, myrcene, and caryophyllene help unravel stress. THC also CBN yields enhanced sedating effects. Linalool and limonene combined with CBD has been examined within an anti-acne treatment. These examples only scratch the surface of most possible synergies made available to us by means of whole plant treatments. Consider all of the medical possibilities waiting for us since the combinational possibility of these compounds are all unlocked.

The thought of the number of lives could be changed for the better by such discoveries is almost overwhelming.

“The entourage effect” is really a term applied to describe drugs using the full range of therapeutic compounds cannabis needs to offer you. A glimpse of the most abundant cannabinoids and terpenes is provided below in both graphics illustrating the properties and advantages of each and every (click on each for expanded versions). As you can see, each of those therapeutic agents that are refined out of THC- and – CBD-only medicines have so much to offer patients handling a wide breadth of symptoms and illnesses.


Scientific Studies

According to NCBI:

Cannabinoids, including tetrahydrocannabinol and cannabidiol, are the most important active constituents of the cannabis plant. Over recent years, cannabinoid-based medicines (CBMs) have become increasingly available to patients in many countries, both as pharmaceutical products and as herbal cannabis (marijuana). While there seems to be a demand for multiple cannabinoid-based therapeutic products, specifically for symptomatic amelioration in chronic diseases, therapeutic effects of different CBMs have only been directly compared in a few clinical studies.

The survey presented here was performed by the International Association for Cannabinoid Medicines (IACM), and is meant to contribute to the understanding of cannabinoid-based medicine by asking patients who used cannabis or cannabinoids detailed questions about their experiences with different methods of intake.

The survey was completed by 953 participants from 31 countries, making this the largest international survey on a wide variety of users of cannabinoid-based medicine performed so far. In general, herbal non-pharmaceutical CBMs received higher appreciation scores by participants than pharmaceutical products containing cannabinoids. However, the number of patients who reported experience with pharmaceutical products was low, limiting conclusions on preferences. Nevertheless, the reported data may be useful for further development of safe and effective medications based on cannabis and single cannabinoids.


That is not to say synthetic, hemp-based, and CBD-only medicines aren’t effective choices for most patients, notably as laws restrict accessibility to alternatives. These sorts of products have served a monumental role either as medication and as a pruning stepping stone.

However, what more can patients get out of whole plant medication? Instrumental in this field of science is Ethan Russo, M.D., a neurologist with long studied cannabis chemicals and their role within your system. We’re not only talking about the well-known THC-CBD label team here even small levels of terpenes (fragrant oils that give cannabis its smell) can make a huge difference.


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